genoTOR™ characterises an individual’s genetic profile linked to mTOR-regulated signalling pathways, mechanisms known to affect the risk of Alzheimer's and dementia. It is now widely accepted that the pathogenesis of Alzheimer’s disease involves defects in cell cycle regulation. Many cellular processes are controlled by the mTOR pathway and differentially expressed mTOR pathway genes may regulate key functions linked to Alzheimer’s disease.
genoTOR™calculates a SNP burden score for 21 different pathways associated with mTOR, providing insight into Alzheimer's disease subjects who phenotypically show similar symptoms, but genotypically may be quite different.
For developers of new Alzheimer’s therapies targeting this pathway, genoTOR™ enables a better understanding of the genetics at an m-TOR related pathway level with a view to identifying patients that may be best suited for enrolment in to clinical trials of based on drug mechanism of action.